Including herbal medicine, complementary and alternative medicine (CAM) is popular worldwide. The traditional Chinese medicine xinkeshu has been widely used to treat coronary heart disease in China. This study was designed to investigate the protective effect and probable mechanism of xinkeshu tablet to atherosclerotic myocardial ischemia rabbit. Rabbits were divided into four groups (n = 12 each) and fed with different diet for 12 weeks: Control (standard diet), Model (high-cholesterol diet), XKS (high-cholesterol diet with 184.8 mg/kg/d xinkeshu), and Atorvastatin (high-cholesterol diet with 5.0 mg/kg/d atorvastatin). Plasma lipoprotein, ECG, endothelium-dependent vessel relaxation, histomorphological study, and expressions of eNOS and VCAM-1 on coronary arteries were assessed. The findings showed that, similar to atorvastatin, xinkeshu presented significant effects on rescuing endothelium-dependent vessel relaxation, inhibiting atherosclerotic progress, preventing myocardial ischemia, and changing eNOS and VCAM-1 expression. However, xinkeshu showed no lipoprotein lowering effect in hypercholesterolemia rabbits. The results of the present study indicated that xinkeshu exerted potent antiatherogenic and anti-ischemic properties on atherosclerotic myocardial ischemia rabbit. An endothelial protecting effect may be involved in the mechanism other than antihyperlipidemic effect.
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机译：包括草药在内的补充和替代医学（CAM）在世界范围内都很流行。中药新科书在中国已广泛用于治疗冠心病。本研究旨在探讨心可舒片对兔动脉粥样硬化性心肌缺血的保护作用及其可能机制。将兔子分成四组（每组12只），并以不同的饮食喂养12周：对照组（标准饮食），模型（高胆固醇饮食），XKS（高胆固醇饮食，每克新丁184.8 mg / kg / d） ，以及阿托伐他汀（高胆固醇饮食，含5.0μmg/ kg / d阿托伐他汀）。评估血浆脂蛋白，心电图，内皮依赖性血管舒张，组织形态学研究以及eNOS和VCAM-1在冠状动脉上的表达。研究结果表明，与阿托伐他汀相似，新科书对挽救内皮依赖性血管舒张，抑制动脉粥样硬化进展，预防心肌缺血以及改变eNOS和VCAM-1表达具有显著作用。但是，新科书在高胆固醇血症兔中未显示脂蛋白降低作用。本研究结果表明，新科书对动脉粥样硬化性心肌缺血具有有效的抗动脉粥样硬化作用和抗缺血作用。除了抗高血脂作用外，内皮保护作用也可能参与其中。
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